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μFocus technology is at the heart of HST's product line for MALDI-TOF MS. Unique, proprietary technology produces thin, disposable, single-use stainless steel targets with hydrophilic islands (μFocus spots) on a hydrophobic surface. The results is precise, concentrated, deposition of sample in precise, well-formed spots.
μFocus targets give you a precisely formed dried droplet spot of predetermined size. You can work with larger (1700-2000 μm) spots and use standard spotting techniques. You can also work with much smaller spots (700-900 μm) that allow you to reduce the amount of matrix used, to maintain optimum matrix to analyte ratio with less concentrated or smaller analyte samples. Many users report 5-10x increases in sensitivity. Because μFocus spots are uniform, you also see improvements in spot-to-spot reproducibility, making quantitative analysis and fingerprint assays more reliable.
Finally, the low cost of these thin, stainless steel sample plates means that you can keep more plates in use, always start with a pristine, clean sample plate, and archive samples after. learn more
HST μFocus sample plates are available for ABI/AB Sciex, Bruker and Shimadzu MALDI-TOF MS instruments.
Find "how to" documentation and other valuable resources in our reference library.